This experiment was conducted at the Experimental Station and in the Laboratory of Vegetable and Floriculture Department, Faculty of Agriculture, Mansoura University during the two successive seasons of 2005/2006 and 2006/2007 to study the effect of fertilization with cattle manure, bio-fertilizer and/or mineral NPK on growth, yield, oil production and chemical composition of coriander plant. Regarding the effect of organic fertilization, the obtained results indicated that the application of cattle manure significantly increased plant height (cm), number of branches/plant, herb dry weight/plant (g), number of umbels/plant, yield of seeds/plant (g), yield of seeds/fed.  (kg), essential oil (%), essential oil yield/plant  (ml), essential oil yield/fed. (liter),  leaves content of chlorophyll a, b and carotenoids (mg/g fresh weight), as well as the percentages of  N, P and K in both seasons. The superiority in all previous traits was for the plants growing in the soil fertilized with the highest level of cattle manure (25 m³/fed.) as compared with the lower levels. The plants fertilized with either 100% NPK or 75% NPK plus the two bio-fertilizers (effective microorganisms and phosphorein) gave the best results in all investigated parameters in both seasons, whereas the least values were recorded by the plants fertilized with the two bio-fertilizers either individually or together. The interaction between cattle manure, bio- and/or NPK treatments were the most effective on the previous parameters. The highest values in all measurements were obtained due to the high cattle manure level (25 m³/fed.) in combination with the two bio-fertilizers plus 75% NPK or 100% NPK alone. Such two superior treatments gave almost equal results which assure the possibility of replacing 25% of the chemical NPK by the use of effective microorganisms plus phosphorein in fertilizing medicinal or aromatic plants such as Coriandrum sativum.