Two field experiments were carried out at Sids Agric. Res. Station, Beni-Suef Governorate, in 2007 and 2008 seasons. The experiment was conducted to evaluate the effect of foliar feeding with B and/or Zn on growth and productivity of the Egyptian cotton Giza 80 cultivar (G. barbadense L.,) to study response of growth, fruiting and yield. Besides the control treatment, two concentrations of both boron (85 and 170 ppm) and zinc (180 and 360 ppm) and their combinations were applied twice; at the start and peak of flowering. The experimental design was randomized complete blocks with four replications. Results revealed that, spraying boron and zinc either separately or in combination generally showed some positive effects on cotton growth, fruiting and yield in comparison with untreated control in both seasons, but such as some of their treatments significantly increased only plant height and number of fruiting branches/plant in 2007 season; number of open bolls/plant, boll weight and seed cotton yield/fad. in both seasons and seed index in 2008 season and significantly decreased fruit shedding % in 2008 season. Across the two studied seasons, the combined application of 85 ppm B and either 180 or 360 ppm Zn exerted the most consistently positive effects on cotton growth and fruiting and gave the highest seed cotton yield. The higher levels of either B or Zn (170 ppm B or 360 ppm Zn) showed no more benefits than those obtained of the lower ones (85 ppm B or 180 ppm Zn), rather than it tended to reduce them in case of boron. It could be concluded from this study that yield of Giza 80 cotton cultivar might be increased by spraying 85 ppm boron + 180 ppm zinc under the environmental conditions of this study or similar of them.