Two field experiments were carried out during the two successive seasons of 2005/06 and 2006/07 at Agricultural Research Station, Faculty of Agriculture, AlexandriaUniversity, to evaluate Giza 168 wheat cultivar response to different cropping systems and nitrogen fertilizer levels. The results indicated that, cropping systems including one cut type berseem and/ or soybean significantly decreased weeds dry weight and increased number of tillers and spikes per square meter, 1000-grain weight and grain yield per feddan in the two seasons. Increasing nitrogen levels up to 80 kg per feddan, significantly decreased weeds dry weight and increased plant height, number of tillers and spikes per square meter, spike length, grain weight, number of grains per spike, 1000- grain weight and grain yield per feddan in both seasons. Application of 80 kg N/ fed. to the cropping systems containing leguminous crops especially the one cut berssem and soybean produced the heaviest grains, highest number of tillers per square meter and grain yield per feddan in the first, second and both seasons, respectively.