The investigation was done to study the effect of Sodium Silicate Pentahydrate (Si) and Glycine betaine (GB) on enhancing salt tolerance of Mango seedlings “El-Gahrawey" cultivar grown under salinity stress. The results indicated that the application of sodium chloride (NaCl) induced a significant reduction in growth parameters and plant development, increasing salinity levels decreased plant leaf number, stem diameter, and stem length as well as fresh and dry weight of leaves. Also, a reduction of chlorophyll was observed in salt-affected plants. Besides, salt stress lead to an accumulation of sodium Na⁺ and a decrease in N, P, K⁺, Ca²⁺, and Mg²⁺ concentrations in mango leaves. However, Combinations of Si and GB sprays was the most effective treatment in alleviating the negative impacts of salt stress in mango, this treatment increased significantly most of the tested parameters under salt stress.