Two filed experiments were conducted during the two summer seasons of 2015 and 2016 in a private Farm at Gemiana village near Belqas City Dakahlia Governorate, Egypt, to study the effect of interaction between deficit irrigation water (60%, 80%, 100% of ETc) and some foliar spray treatments (nano iron, nano zinc, nano silicon and yeast extract) on plant growth parameters, chemical composition of leaves as photosynthetic pigments (Chl. a, Chl. b, total Chl. a+b), leaf mineral percentages (N, P, K) proline, yield and water use efficiency (WUE) of tomato plants (Fayruz hybrid) under drip irrigation system. A strip-plot design with three replicates was used. The vertical plots were allocated to the deficit irrigation, whereas the horizontal-plots were devoted to foliar spray treatments. Results revealed that the interaction among irrigation tomato plants at the level of 80 % Etc and spraying with different nano particles at different concentration or yeast extract significantly increased all aforementioned parameters, meanwhile deficit irrigation water treatments improved leaves proline content and WUE in both growing seasons. The best interaction treatment for increasing plant growth parameters, chemical constitutes of leaves as photosynthetic pigments (Chl. a, Chl. b, total Chl. a+b) leaf mineral percentages (N, P, K) early and total yield is irrigation treatment with 80 % Etc and spraying with nano Si at 12 ppm and can be recommended to increase growth and productivity tomato plants of under similar conditions of this study.