Positive response of cowpea to three levels (4, 6 and 8 t/fed.) of MOF “the mixture of 25% vermicompost+ 25% chicken manure+25% cow dump+25% plant composted" alone and in combination with beneficial microbes B.M. (the mixture of Azotobacter, Bacillus megatherium and Bacillus circulance) and three times of vermitea (VTS3) were adding (3 times on soil drench) were studied. Two field experiments were carried out at a private farm El Amryia, Egypt in two different sites. Experimental field was laid out with 13 treatments in RCBD with three replicates. On results, T13=MOF (8T/fed.)+B.M.+VTS3 gave the highest mean values of plant height (281.5cm), No. of branches (12.7), No. of pods/plant (37.6), total chlorophyll (60.25 SPAD) in leaves, pod weight (141.0 g/plant) and total pod yield (2924.704 kg/fed) as an average of both sites. The lowest means values at T1 “the control" were (81.6 cm, 2.8, 10.6, 16.8 SPAD, 39.3 g/plant and 815.555 kg/fed as an average of both sites, respectively). As well as; T13 lead to significant increases in grain quality of (N, P and K % and proteins %) were (4.7,0.5,0.9 % and 29.8%, respectively) compared to T1 (1.0, 0.11, 0.21and 6.7%, respectively). While T13 was caused significantly increases in mean values by the mixture of bio-organic fertilizers and bio-pesticides provided best results in vegetative growth, total pod yield and grain quality more than T1 in poor nutrients soil. Organic cowpea was produced by bio-organic fertilizers “MOF+B.M." and vermitea “VTS" really “chemicals free", health protection, cost lowest and environmental friendly.