This study has proceeded during 2018 and 2019 vintages for resolving the major problems which facing Crimson seedless grapevines production e.g., lack of anthocyanin accumulation at ripening and bunch rot incidence by Botrytis cinerea. So, Crimson grapevines were defoliated at pre- and post-blooming by removing eight basal leaves or by removing four leaves before and after blooming (three treatments) in addition to the control. The pre-blooming defoliation of grapevines enhanced vegetative growth conditions and gave a satisfying yield with the good coloring of cluster berries and fewer rot infections.