Two field experiments were carried out at Sakha Agricultural Research Station, Kafr El-Sheikh Governorate, North Nile Delta region during the two growing seasons (2008/2009 and 2009/2010) to find out the response of some wheat cultivars to different irrigation levels. Four wheat cultivars were subjected to 3 irrigation levels based on: soil moisture depletion (SMD) in the effective root zone, Ibrahim's equation (ET_P = 0.1642 + 0.8 EP) and watering till 5.0 cm above the soil surface. The wheat cultivars were: Sakha 93, Giza 168, Gemmeiza 7 and Gemmeiza 9. The most important results could be summarized as follows: The highest mean values of grain yield were recorded from Giza 168 wheat cultivar and the lowest mean values were obtained from Gemmeiza 9. Concerning irrigation treatments, the mean values of wheat grain yield can be descended in order as follows; irrigation till 5.0 cm > Ibrahim's equation > soil moisture depletion (SMD). For straw yield, the highest mean values were recorded from Sakha 93 and Gemmeiza 7 with values of 6444.31 and 6486.03 kg/fed., respectively. Regarding irrigation treatments the highest mean values were recorded with Ibrahim's equation and the mean values were 6175.27 and 6161.43 kg/fed. in the first and second growing seasons, respectively. The mean values for biological yield, the highest mean values were recorded under Giza 168 wheat cultivar in the two growing seasons and with irrigation till 5.0 cm above soil surface. The mean values          of 1000 grain weight can be descended in order as follows: Giza 168 > Sakha 93 > Gemmeiza 7 > Gemmeiza 9 for irrigation treatments, the highest mean values were recorded with irrigation till 5.0 cm above soil surface. Moreover, the highest mean values of harvest index were recorded under Gemmeiza 9 wheat cultivar and under irrigation till 5.0 cm above soil surface. For water relations, the mean values of water utilization efficiency (W.Ut.E) and water use efficiency (W.U.E.) were obtained from Giza 168 wheat cultivar and irrigation according to soil moisture depletion (SMD). The values of actual waterconsumptive use for all studied cultivars were rather similar but under Gemmeiza 9 the mean values were slightly higher. While, the highest found mean values were under irrigation till 5.0 cm above soil surface. Values of water applied for the studied wheat cultivars can be descended in order as followsGiza 168 > Gemmeiza 9 > Gemmeiza 7 > Sakha 93. While, for irrigation treatments the mean values can be descended in order irrigation till 5.0 cm > SMD > Ibrahim's equation.