This experiment was carried out during the two successive seasons2018 and2019 on nine years old "Anna" apple trees (Malus domestica, Borkh) budded on Malus rootstock, planted at 3×4meters apart (350trees/fed.) in clay soil under drip irrigation system in a private orchard located at El-Gharbia governorate, Egypt to study the efficacy of some chemical structure of pesticides on yield, fruit quality and infection with fungal diseases (scab and powdery mildew diseases). The used  chemical structure were: Carbendazim 80%, Captan 50%, Captan 80%, Sulfur 95%, Thiophanate methyl 70%, Kresomix  methyl50%, Difenoconazole25%, Cyproconazole40%, Copper oxide56.35%, Dondine 40%, Epoxiconazole12.5%, Metalaxy-m +azoxystrobin39%, Difenoconazole + propiconazole30%, Thifluzamide + difenoconazole27.5%,  each of this chemical structure were sprayed 4times; before flowering in mid-February, mid-March, after full bloom in the end of March and once after fruit set in mid-May.The main results can be summarized as follows:Apple trees sprayed with Carbendazim , Captan 50%, Captan80%, Sulfur95%, Thiophanat methyl,Copper oxide, Dondine, Metalaxy-m +Azoxystrobin, Epoxiconazole, Difenoconazole + Propiconazole and Thifluzamide+ difenoconazole.Gave the best results in fighting the infection of powdery mildew and improved vegetative growth and gave better results in the total number of flowers and fruit set percentage. Spraying one of the following chemical compounds with the same previous vehicles reduced infection with powdery mildew and apple scabies on trees, which led to improved and increased yield, number and weight of fruits, also improved the quality of the fruits; increasing TSS, coloration, as well as the percentage of the anthocyanin in the peel of the fruit and decreasing acidity.