The present research was carried out at experimental station of faculty of agriculture, Mansura University Dakahlia Governorate, Egypt, during successive season of 2011 to study the effect of some plant growth regulators treatments i.e. control, IAA at concentration of 6 ppm, GA3 at concentration of 10 ppm, IAA at 3 ppm + GA3 at 5 ppm and IAA at 6 ppm + GA3 at 10 ppm,  and its soaking time i.e. at (10 minutes, 20 minutes and 30 minutes on some germination and vegetative parameters of some potato (Solanum tuberosum L.) cultivars i.e. Cara, Draga and  Spunta.The main results could be summarized as follows: Concerning cultivars performance, results showed that Cara cultivar recorded highest germination index followed by Spunta cultivar without significant differences between them. Draga cultivar recorded tallest plant, highest fresh weight and dry weight in gm/plant followed by Cara cultivar for plant height only and followed by spunta for fresh and dry weight without significant differences between them. Regarding to plant growth regulators effects, the results indicated that there are a significant differences between growth regulators treatments on germination index, mean germination time, plant height, fresh and dry weight of tubers.  Highest values of germination index percentage, plant height and fresh and dry weight of tubers were obtained from soaking tubers in GA3 at 10 ppm plus IAA at 6 ppm. While, soaking tubers in GA3 at concentration of 10 ppm produced highest value of mean germination time. Regarding to the effect of soaking time of growth regulators, results clearly indicated that there is a significant differences between times of soaking on fresh weight per plant. Soaking tubers for 30 minutes produced highest values of fresh weight followed by soaking for 20 minutes without significant differences between them. The interaction among cultivars and growth regulator treatments recorded significant differences on mean germination time, fresh weight and dry weight. The objectives of this work were aimed to evaluate the effect some growth regulators, soaking times and their interactions on encouragement germination capacity of some potato tuber cultivars.