The highly polymorphic in sweet melon for many commercial traits providing seemingly endless possibilities for genetic improvement. The main objective of current study was to estimate of genetic behavior and obtain the genetic parameters of sweet melon advanced lines (Cucumis melo L. var. aegyptiacus). Eight inbred lines were developed from previous study using a pedigree selection method. The selected inbred lines were crossed according to factorial mating design generated 16 crosses. The additive genetic variance played an important role in the inheritance of yield and most yield component traits. Female variance (σ²_f) appeared to be larger than male variance (σ²_m) for the most quality traits except for taste. The magnitudes of additive genetic variance (σ²_A) were lower than their non-additive including dominance (σ²_D) for all studied yield traits, except for number of male flowers per plant and fruit length. The MAGD105, MAGD106 and MAGD107 are promising lines that could be used in farther improvement programs.