The field experiments were conducted at Sakha Agricultural Research Station at Kafr El-Sheikh Governorate, Egypt, during the growing seasons of 2009 and 2010 to preparing the suitable agricultural managements practices (planting date, plant population (hill spacing) and nitrogen fertilizer level) for new promising hybrid cotton (Giza 77 x Pima S6). The first experiment (detriment the suitable planting date) was grown under three planting dates 1st April, 15th April and 1st May. The randomized complete block design was used with four replications. The second experiment (detriment the suitable plant population (hill spacing) and nitrogen fertilizer level) were grown under split plot design. The main plots involved the three hill spacing (20, 25, and 30 cm between hills) and the sub plots included three nitrogen fertilizer levels (45, 60 and 75 kg N /fed.). The results indicated that early planting date in 1st April significantly increased seed cotton yield/fed. due to the increase of number of open bolls /plant and boll weight. Increasing hill spacing from 20 to 30 cm (decreasing plant population) significantly increased number of sympodia /plant, number of open bolls /plant, boll weight and seed cotton yield /fed. While plant height, first sympodial position, earliness % and lint % decreased. As for nitrogen levels, plant height, number of sympodia /plant, first sympodial position, number of open bolls /plant, boll weight, seed index and seed cotton yield/fed. increased by increasing nitrogen levels. The interaction between plant population (hill spacing) and nitrogen fertilizer levels gave significantly effect on all character studied except lint % and fiber properties. The interaction 30 cm between hills and 75 kg N /fed gave the highest number of sympodia plant, number of open bolls, boll weight, seed index and seed cotton yield /fed. The studied treatments did not exhibit any significant effect on all fiber properties. It could be concluded that the highest seed cotton yield/fed. was obtained from planting the new promising hybrid cotton Giza 77 x Pima S6 early in 1st April under 30 cm hill spacing and 75 kg N/fed. under Sakha location.