The role of some plant extracts such as scran and nerium, malathion and the mixture of them in protecting wheat seed from storage insects (Sitophilus oryzae L.,)  and keeping its quality during storage is demonstrated. The objective of this study was to determine the effect plant extracts, malathion and the mixture of them on protecting seed of some wheat varieties (Sakha 93,Gemmiza 10 and Giza 168) from storage insects (Sitophilus oryzae L.,) as well as its effects on seed quality and insect infestation during different storage periods (0, 6 and 18 months). The main results revealed that: Treating rice weevils with the recommended dose of malathion resulted 100% mortality, meanwhile treating rice weevils with (half dose of malathion+ scran or nerium ethanol extract) increased mortality percentage more than scran, nerium  extracts or half dose of malathion. Extend  storage period after treatment for 6 and 18 months  increased gradually insect infestation and seed dry weight loss and decreased germination percentage, seed and seedlings vigour and carbohydrate percentage, meanwhile seed protein  percentage increased with prolong the storage period. Seeds of wheat variety 168 were the least in insect infestation and seed dry loss percentages comparing varieties Gemmiza 10 and Sakha 93. Treating wheat seed with the recommended dose of malathion or mixed with plant extracts or half dose mixed with plant extracts maintains high seed quality comparing the untreated seed. Generally, seeds of wheat varieties (Giza 168, Sakha 93 and Gemmiza 10) could be store for 18 months with maintain good quality seed by treating with malathion (recommended dose) or half dose mixed with nerium or scran extracts.