This study aimed to study the toxic effects of wood extracts from some timber trees belong to Family Meliaceae against Psammotermes hybostoma at the Tropical Farm, Aswan Botanical Garden and Faculty of Science, Aswan Univ. during winter 2011 and 2012. The meliaceous trees were Khaya senegalensis, K. ivorensis, Swietenia mahagoni, S. macrophylla, Azadirachta indica and Melia azedarach. Results pointed out that S. macrophylla followed by A. indica produced the highest values of total extractives while, M. azedarach produced the lowest one in the two seasons. Using water as a solvent produced the highest values of all wood extractives compared to the other solvents. Moreover, increasing concentrations of the different wood extracts up to 350 mg/l in winter resulted in a gradual increasing of mortality percentage for the 3rd instars of termite. Using alcohol + benzene as a solvent extract for K. senegalensis followed by M. azaderach caused the highest values of mortality percentage for P. hybostoma compared to the other wood extracts. On the other hand, wood extract by benzene alone for M. azaderach followed by K. senegalensis led to the most toxic effects, while S. mahogany benzene extract led to the lowest one compared to the other treatments. According to LC 90 and LC 50 values, results revealed that alcohol + benzene extract or benzene alone of the tested trees at 300 and 150 ppm, respectively was highly toxic to P. hybostoma 3rd instars worker.