The experiment was conducted to evaluate cantaloupe yield, fruits quality and storability in response to different levels of NPK and biofertilizer. The following treatments were studied in split plot design with four levels of NPK, (untreated (control), 50-25-50 kg  NPK/fed., 100-50-100 kg  NPK/fed. and 150-100-150 kg NPK/fed.). Biofertilizers used with two rates, (untreated (control) and  200gm microbein + 300gm phosphorien /fed.). All mineral fertilizer levels and the biofertilizer significantly increased total yield/plot, total yield/fed. (ton) and average weight of cantaloupe fruits compared with control. The combination between mineral fertilizer levels and biofertilizer gave the highest total yield/plot, total yield/fed. (ton) and average fruit weight compared with individual application. The fruits quality parameters increased by applied mineral fertilizers or biofertilizer only or combination  at harvest. Application mineral fertilizers and biofertilizer increased antioxidant capacity for fruits. The pulp of fruits become more darkening, yellow and less green with improve the color and their clarity especially with the utilization of biofertilizer application. All fruits quality parameters decreased at the end of storage as compared with quality parameters at harvest but, the mineral fertilizers and bio in single application or in combinations reduced this decrement during  both seasons.