The present study was undertaken with a view to determine the extent of relationship between seed cotton yield and other economic traits of F₂, F₃ and F₄ generations in the two Egyptian cotton crosses i.e., cross I [({Giza 89 x Giza 85} x {Giza 86 x Giza 81}) x ({Giza 83 x Giza 80} x Giza 89)] and cross II [(Giza 85 x Giza 86) x ({Giza 83 x Giza 80} x Giza 89)]. The F₂, F₃ and F₄ generations in the two crosses were grown at Sakha Experimental farm, Cotton Research Institute, Agricultural Research Center, Egypt during 2008, 2009 and 2010 seasons, respectively. The mean squares obtained from analysis of variance showed highly significant (P≤0.01) differences for most studied traits of F₂, F₃ and F₄ generations in the two crosses. For the two crosses, the best mean values for boll weight (3.27 and 3.39 g) and 2.5% span length (33.22 and 32.84 mm) traits were detected in F₄ generation, seed cotton yield/plant (175.88 and 197.09 g) and uniformity index (87.01 and 86.54 %) traits in F₃ generation and fiber fineness (3.75 and 3.63) in F₂ generation. While, lint percentage (40.68 and 41.39 %) and fiber strength (10.32 and 10.44 g/tex) traits exhibited highest mean values of the crosses I and II in F₄ and F₃ generations, respectively. In general the magnitude of genotypic correlation coefficient was higher than those of phenotypic correlations coefficient of most studied traits for F₂, F₃ and F₄ generations in the two crosses. Seed cotton yield for the two crosses exhibited positive and highly significant associations with lint percentage, 2.5% span length, fiber fineness and fiber strength traits in F₂ generation and with lint percentage and 2.5% span length traits in F₃ and F₄ generations, while, the correlation changed for fiber fineness and fiber strength in F₃ and F₄ generations. 2.5% span length, fiber fineness, fiber strength and uniformity index for the two crosses in F₂, F₃ and F₄ generations had a highly significant positive correlations with boll weight. Lint percentage showed positive and highly significant associations with fiber fineness for F₃ generation in the cross I and with fiber fineness and strength traits for the three generations in the cross II. These results indicating that, the two crosses could be used in improving yield and fiber quality in Egyptian cotton.