This study was carried out at laboratory and greenhouse of Agricultural Botany Department, Faculty of Agriculture, KafrelsheikhUniversity during two winter seasons of 2009 and 2010. The main objective of this study is: Effect of two treatment of bacterial endophytes strains Azotobacter chrocooccum (E1) and Pseudomonas sp. (E2) individually whether as grains soaking and foliar application on growth and yield parameters of two wheat plants (Triticum aestivum L.) cultivars (Sakha 93 and Gmiza 9) grown under three levels of irrigation water deficit stress 75, 50 and 25 % field capacity. Growth parameters that were take into account were plant height, number of leaf/plant, flag leaf area, fresh and dry weight/plant. In addition, wheat yield parameters included spike length and dry weight, number of spikelets/spike and grains number/spike. Generally, irrigation water deficit have an undesirable effect on growth and yield parameters of the tested wheat cultivars. Application of Azotobacter chrocooccum (E1) and Pseudomonas sp. (E2) strains individually were carried out by spray foliar and grains soaking treatments increased the tested vegetative and yield growth parameters for two cultivars, after 40, 70 and 130 days from planting compared with untreated plant. Entophytic bacterial strains treatments play an important role in protection of wheat plants against the adverse effects of drought stress, improve water productivity and will lead to significant water savings for irrigation sector.