This research work was performed to study the interaction between some natural compounds , humic acids and pruning lateral branches of cantaloupe plants (Cucumus melo L.) cv Imperial were planting at Ali Moubarak  Station,South Tahrir, El Behera Governorate during the two successive seasons of 2008\2009 and 2009\2010. The experimental design was split plot with four replicates having pruning lateral branches at reaction in the main plots and spraying some natural compounds, were randomly distributed in the sub plots. Each sub plot had one ridge with dimensions of 10 m long and 1m width .Planting distance was 50 cm apart.  Each sub plot was content on 20 plants. Obtained results showed the superiority of without pruning plant treatments followed by the pruning lateral branches in terms of vegetative growth, fruit and yield characters. Using spraying garlic extract at a rate of 200 ppm/feddan or spraying amino acid at a rate of 200 ppm/feddan increased plant content of N, P, K and some micro nutrients than the other treatments. In addition, the mentioned treatments improved the vegetative growth and fruit physical and chemical characters .Early and total yield were increased under spraying garlic or spraying sucrose at a rate of 500 ppm\feddan. Lowest vegetative growth, fruit and yield characters were obtained from that without spraying treatments (control).