Two field Experiments were carried out in summer seasons of 2008 and 2009 at the Experimental Farm of Rice Research section Agricultural Research station, El-Gemmiza, Gharbia Governorate. This investigation was conducted to study the response of two rice cultivars (Giza 178 and Egyptian Hybrid 1), Three seedling ages (15, 20 and 25 days after planting) and three transplanting spaces (20 × 20, 25 × 25 and 30 × 30 cm) as well as their interactions on growth characters, yield and its attributes. The main results could be summarized as follows: cultivars significantly differed for all traits, Egyptian Hybrid 1 variety produced the maximum number of tillers / m², number of panicle / m², panicle length (cm) , number of total grains / panicle, 1000- grain weight (g) and grain yield (t/fed). While lowest values of these traits were recorded when using Giza 178 cultivar. Seedling ages had asignificant effect on all studied charactarist. Younger seedlings (15 day old) produced significantly the highest values. While the minimum values of the previous traits were obtained when plants were transplanting at (25 day old) seedlings. Plant spacing significantly differed for all traits. Wider spacing (30×  30 cm) gave maximum number of tillers/ m², number of panicle/ m², panicle length (cm), number of total grains / panicle, 1000- grain weight (g). and grain yield (t/fed) While closer spacing (20×  20 cm) gave the lowest values. Significant effect for the the interaction between the three factors under study. The highest values of all traits were recorded when using Egyptian Hybrid 1 cultivar, youngest seedling age (15 day old) and widest spacing between hills (30×  30 cm).On the other hand, the lowest values were recorded when using Giza 178 cultivar, the oldest seedling age (25 day old) and closest spacing between hills (20×20cm)in the both seasons. In general it could be recommended that, using Egyptian Hybrid 1 with seedling age 15 days and plant spacing of 30 × 30 cm under transplanting.