The aim of this study was to determine the effect of selenium treatments (rates and time of application) as foliar spraying on growth and  grain yield of wheat Sakha 93 cultivar. Two field experiments were selected for the study (Station Farm at Mansoura and Kalabsho & Zayian region, Faculty of Agriculture, MansouraUniversity during the winter season of 2010/2011. A randomized complete block design with four replications was used. Selenium foliar spraying significantly increased (p<0.05) the growth and yield of wheat. The highest values of growth, grain yield and its components were associated with spraying wheat plants twice with 7.5 g selenium/fed after 50 and 70 days from sowing. This treatment followed by foliar spraying after 70 days from sowing only with the same levels of selenium, then foliar spraying after 50 days from sowing only with also the same levels of selenium with significant differences (p<0.05) in both locations. In conclusion, foliar spraying wheat plants twice with selenium at the rate of 7.5 g/fed after 50 and 70 days from sowing to maximize growth and productivity under the environmental conditions at both locations