Rice is a very important cereal in Egypt and allover the world. In Egypt, it is a crucial food crop because of shortage in wheat production. Because of water shortage, in Egypt, trials were conducted to find out the effect of water deficit combined with fertilizer combinations on yield and yield components of hybrid one rice cultivar. Two field experiments were carried out at the Experimental Farm of Rice Research and TrainingCenter, Sakha, Kafr El-Sheikh, Egypt, during 2011 and 2012, rice growing seasons. A split plot design with three replications was used. The main plots were devoted to four irrigation intervals; 3, 6, 9 and 12 days. The sub plots were occupied by seven fertilizer combinations; control (without fertilizer), recommended 100% NPK, 2.10 t/fed. compost, 25  , 50  , 75  , 100 % NPK+ 2.10 t/fed. compost.  All agricultural practices were applied as recommended for rice Hybrid one cultivar. The main results revealed that yield and its components were significantly affected by irrigation intervals. Number of panicles/m² , panicle weight, 1000-grain weight, grain yield (t/fed) and harvest index  significantly decreased as irrigation intervals prolonged up to 12 days in both seasons. On the other hand, no significant differences were found between 3-day and 6- day irrigation intervals on yield and yield attributes. The fertilizer combinations had highly significant effect on yield and yield attributes of hybrid one rice cultivar. The highest values of Leaf area index, dry matter weight, plant height, number of panicles/m², panicle weight, 1000-grain weight, grain yield (t/fed) and harvest index were recorded in plots fertilized with full recommended dose of nitrogen (69 kg), phosphorus (15.50 kg) and potassium (24 kg) followed by these fertilized with full dose of NPK without any compost or 75 % recommended dose of NPK + compost. The interaction between irrigation every three days and fertilization with 100 % NPK + compost or 75 % NPK + compost gave the highest values of number of panicles/m², panicle weight,1000-grain weight, grain yield and harvest index.