Calli characters and its regeneration of 8 bread wheat genotypes were evaluated under water stress using PEG. Certain physiological aspects including ; chlorophylls, total sugars and proline content were also examined. The data  showed a significant differences between the examined genotypes in response to drought stress conditions. However, genotypes Gemmeiza 10, Misr 1 and Gemmeiza 7 were found to be more stable against drought conditions in comparison with the other examined genotypes and genotypes Sakha 8 and Sakha 94 seemed to be more sensitive in this respect.