Two field experiments were conducted at  Rice Research and Training Center ( RRTC ) Farm, Kafr-El-Sheikh Governorate, Egypt, during two successive seasons of 2009 and 2010. The main objectives of this study are; identifying both the optimum seeding rates and hill spacing to increase the yield of hybrid rice seed for the hybrid IR69625A/Giza181R (2046H), this study included, three seeding rates for cytoplasmic male sterile line (6kg/fed, 8kg/fed and 10kg/fed) and three hill spacing ( 15×10, 15×15  and 15× 20cm).The treatments were arranged in split plot design with three replications, where seeding rates distributed as main plots while hill spacing were allocated in the sub plots. Data were recorded on different traits relating to yield and its components .             The results showed that,  the seed rates had highest significant on plant height , panicle weight, panicle length, panicle exsertion, no. of spikelets/ panicle seed set, 1000 grain weight and  grain yield . The optimum treatment to produce high quantity of hybrid rice seed from the hybrid combination of  IR69625A/Giza181R (SK.2046H) was 8kg seeds/fed, for the seeding rate.           Moreover, hill spacing treatments had highest significant on all studied characters,except no. of panicles/m² character. The best hill spacing  for cytoplamic male sterile was 15 x 15cm.           The interaction between seed rates and hill spacing was significant for all studied characters.            It could be concluded that the optimum treatments to produce high quantity of hybrid seed from the hybrid combination IR69625A/Giza 181R (SK.2046H) was 8kg seeds/fed  for the seeding rate and (15×15cm) for hill spacing, because this treatment was recorded the highest values of panicle exsertion (81.61%),seed set (46.06%) and grain yield (1.32 t/fed).