This study was planned to reduce or replace chemical fertilizer with organic and bio-fertilizers in parsley productivity. Three FYM rates (2 t./fed, 4 t./fed and 6 t./fed) and four biofertilizers treatments ( zero, yeast extract, biofertilizers mix, S.mix +bio+yeast) and Super mix foliar application were studied compared to recommended NPK during the two successive winter seasons of 2014/2015 and 2015/2016. The obtained results indicated that vegetative growth, seed yield and essential oil %, total carbohydrates, vitamin c, total chlorophyll and NPK contents were increased with increasing FYM rate to reach the maximum values in 6t./fed rate. On the other hand, biofertilizers treatments improved vegetative growth, seed yield and essential oil % with the superiority of (S.mix +bio+yeast) treatment during the two growing seasons. It could be recommended with 6 t./fed. FYM and (S.mix +bio+yeast)  or yeast biofertilization treatments to obtain best growth, seed yield and essential oil percentage, as well as, reducing pollution and keep human health.