Toward reading the impact of treating by away of  magnetized water and spraying through various bio-activators on productivity and chemical composition of lettuce, two 2 trials were done at the Experimental Station Farm, Faculty of Agriculture, Mansoura University, Egypt, throughout 2015/2016 and 2016/2017 years. The field experimentations were done in a strip-plot design by way of 4 replicates. The greatest averages of plant fresh and dry heaviness, entire yield/fed, chlorophyll (chlo.) a, chlo. b and entire chlo., TSS (TSS) %, entire carbohydrates %, crude protein % and entire sugars % , vit-C and vit-E contents in addition to the minimum averages of nitrate and nitrite contents were registered because of irrigation by away of  magnetized water. Spraying by away of  yeast extract (100 ml/liter) produced the highest standards of plant fresh and dry heaviness, entire yield/fed, chlo. a, b and entire chlo., TSS %, entire carbohydrates %, protein % and entire sugars %, vit-C and vit-E contents in addition to the minimum averages of nitrate and nitrite contents. It can be accomplished that irrigation lettuce plants by away of  magnetized water in addition spraying by away of  yeast extract (100 ml for each liter water) or liquid humic acid (1.0 ml for each liter water) to achieve  towering growth, output  and ingredients of lettuce (Balady cultivar) over the ecological circumstances of Mansoura district, Dakahlia Governorate, Egypt.