This study was carried out during two successive seasons (2015 & 2016) to study the effect of foliar applications of selenium (Se) at 5 mg/L, tryptophan (TRP)  and methionine (MET)  at  ( 50 or 100 mg/L)  for both  on twelve-year old Superior Seedless grapevines. The chosen vines were irrigated under surface irrigation system, trellised by Gable supporting system, and spaced at 1.75 x 3 meters apart, whereas; the vines were pruned at the second week of Dec. during two seasons. Accordingly to the results which appear that foliar applications of Se, TRP and MET improved the growth characters, the physical characteristics of cluster and berries, also; yield/vine, leaves petioles nutrient content (N, P and K), total carbohydrates in canes and total chlorophyll in leaves as well as total free amino acids in berry juice compared with control during in two seasons. In this concern, the best results obtained by using of foliar application with TRP in combined with Se.  Also, Se treatment had positive effects on T.S.S.%, but reduced total acidity% in berry juice compared with the control treatment in both seasons, while; the best results in this case obtained by foliar application with MET in combined with Se.  The increasing in total free amino acids content in berry juice was increased with increasing foliar application of both TRP and MET.