Two field experiments were carried out in a private farm at Gamassa district, Belqas Center, Dakahlia Governorate, Egypt, during the two successive summer growing seasons of 2013 and 2014 to study the effect of mineral nitrogen fertilizer rates, organic manure and foliar fertilization treatments with biofertilizers , biostimulants as well as their interactions on growth and yield of cantaloupe cv. Primal. The field experiments were laid-out in strip-split plot design with three replications. The most important results obtained from this investigation can be summarized as follows:      Increasing mineral nitrogen fertilizer rates from 75 to 100 and 125 kg N/fed tended to increase growth, yield and its components, thus the highest values of these characters were resulted from adding the highest rate of nitrogen fertilizer (125 kg N/fed) in both seasons. Organic fertilizing of cantaloupe plants with chicken manure at the rate of 15 m³/fed significantly increased  growth, yield and its components as compared with control treatment (without organic manure) in both seasons. Foliar spraying cantaloupe plants with yeast extract at rate of 5g /1L significantly surpassed other treatments (without, spraying with EM or Agrispon) and produced the highest values of all studied growth, yield and its components in both seasons. It can be recommended that organic fertilizing cantaloupe with 15 m³ chicken manure/fed and foliar spraying plants with yeast extract and mineral fertilizing with 100 kg N/fed in order to increase cantaloupe yield over the control treatment and reduce the environment pollution and production costs under the environmental conditions of Dakahlia Governorate, Egypt.