A laboratory experiment was carried out under the laboratory conditions of the Experimental Station of Agronomy Department, Faculty of Agriculture, Mansoura University, Egypt, from 15^th May to 15^th November, 2013. The purpose of the experiment was to assess the effect of some chemical insecticides treatment (phosphine, malathion and deltamethrin) with various rates on storage efficacy of wheat grains under the environmental conditions of Dakahlia Governorate, Egypt, during different storage periods (0, 3 and 6 months after harvesting). The most important results obtained from this investigation can be summarized as follows: Storage periods of wheat grains had a significant effect on storage efficacy traits. Increasing storage periods of wheat grains from 3 to 6 months significantly decreased storage efficacy traits over all studied grain treatments. Treating wheat grains with some chemical insecticides treatment i.e. phosphine at the rates of 5, 7 and 9 ppm, malathion at the rates of 6, 8 and 10 ppm and deltamethrin at the rates of 0.75, 1.00 and 1.25 ppm had a significant effect on storage efficacy traits as compared with both control treatments. It can be recommended treating grains of wheat (Gemmiza 10) with phosphine at the rates of 7 or 9 ppm deltamethrin at the rates of 1.00 or 1.25 ppm to increase storage efficacy under the environmental conditions of Dakahlia Governorate, Egypt.