A laboratory experiment was carried out under the laboratory conditions of the Experimental Station of Agronomy Department, Faculty of Agriculture, Mansoura University, Egypt, from 15^th May to 15^th November, 2013. The purpose of the experiment was to assess the effect of some plant oils treatment (neem, coriander and mustard) on storage efficacy of wheat grains under the environmental conditions of Dakahlia Governorate, Egypt, during different storage periods (0, 3 and 6 months after harvesting). The most important results obtained from this investigation can be summarized as follows: Storage periods of wheat grains had a significant effect on storage efficacy traits. Increasing storage periods of wheat grains from 3 to 6 months significantly increased storage efficacy traits over all studied grain treatments. Treating wheat grains with some plant oils i.e. neem oil at the rates of 7.5, 15.0 and 22.5%, coriander and mustard oils at the rates of 5.0, 10.0 and 15.0% had a significant effect on storage efficacy traits as compared with both control treatments. It can be recommended treating grains of wheat (Gemmiza 10) with some plant oils (neem oil at the rates of 15.0 and 22.5% and mustard oil at the rates of 10.0 and 15.0 %) as an alternative way of use chemicals insecticides to increase storage efficacy and reduce environmental pollution and preservation of human health under the environmental conditions of Dakahlia Governorate, Egypt.