Two field experiments were conducted at Bardies, Sohag Governorate, Egypt, during the summer seasons of 2011 and 2012. The objective of this investigation aimed to study the response of some maize hybrids to different nitrogen fertilization levels and filter mud cake. A split-split plot design with three replications was used. Two Maize Hybrids (H₁- Single cross Watania-4 and H₂- Three way cross-310) were allocated in the main plots. Nitrogen fertilization levels (N₁- 80, N₂- 100 and N₃ 120 kg N/fed) were distributed in the sub plots. While, organic fertilizer (filter mud cake B₁- Control (without addition, B₂- one ton/fed, B₃- 1.5 ton/fed and B₄- 2 ton/fed) were randomly distributed in the sub-sub plots. The results indicated that single cross Watania-4 surpassed significantly three way cross 310 in ear length cm, ear diameter cm, number of rows/ear, number of kernel/ear, ear weight gm, grains weight/ear gm, 100-grain weight gm and grain yield (ardab/feddan). There were gradual and significant increases in ear length cm, ear diameter cm, number of rows/ear, number of kernel/ear, ear weight gm, grains weight/ear gm, 100-grain weight gm and grain yield (ardab/feddan) resulted from raising mineral N-level from 80 to 100 and 120 kg N/fed. There were significant differences in the studied traits as affected by the organic fertilizer (filter mud cake) in both seasons. Under Sohag Governorate conditions of the present work, growing single cross Watania-4 fertilized with 120 N/fed and applied 2.0 ton filter mud cake that were recommended to get the maximum grain yield (ardab/feddan).