This work was carried out during 2018 and 2019 seasons for studying the effects of pre-harvest treatment by Aminoethoxyvinylglycine (AVG), 1-Naphthaleneacetic acid (NAA), P-Coumaric acid and Lyso–phosphatidylethanolamine (lisophos) on preharvest drop, fruit quality and fruit shelf life of ‘Anna' apple fruit. Seven treatments used as foliar application of AVG at 300 ppm, AVG at 300 ppm plus P-Coumaric acid at 50 mM or lisophos at 400 ppm, NAA at 20 ppm, NAA at 20 ppm plus P- Coumaric acid at 50 mM or lisophos at 400 ppm and water application as a control were applied. Results showed that application of AVG or AVG plus lisophos reduced preharvest fruits drop and increased yield, fruit firmness, acidity, starch and chlorophyll (a, b) contents as compared with control and other treatments in both seasons. On the other hand, fruit weight, size, length and diameter were increased by NAA or NAA plus lisophos relative to the control and other treatments in both seasons. Also, spraying NAA followed by P-coumaric acid significantly increased fruit drop%, SSC, total sugars and anthocyanin contents but decreased fruit firmness during both seasons. Concerning shelf life period, all preharvest of AVG treatments significantly decreased the loss % of firmness, fruit weight loss, fruit decay %, SSC and anthocyanin contents compared to other treatments. it could be concluded that, pre harvest foliar application with AVG at 300 ppm alone  or  followed by lisophos at 400 ppm reduced preharvest fruits drop % and fruit decay %  and increased yield and fruit firmness. Thus, both treatment are recommended for apple growers to obtain the best yield and prolong the handling season with acceptable fruit coloration.