Two field experiments were conducted at the Farm of Sakha Agricultural Research Station, Sakha,Kafr- ELsheikh, Egypt during 2012 and 2013 summer seasons. The study aimed to find out the proper nitrogen levels of drill seeded rice of Giza179 rice cultivar under prolonged irrigation interval. The experiment was performed in strip-plot design with four replications. The horizontal plots were devoted to three irrigation treatments; continuous flooding (CF) every 3 days, irrigation every 6 and 9 days. The nitrogen levels Viz; 0, 110, 165 and 220 kg Nha^-1 were distributed in the vertical plots. The main results revealed that the growth characteristics as well as grain yield and its attributes were significantly affected by the irrigation intervals in both season of study. flag leaf area, leaf area index,chlorophyll content, plant height, number of tillers/m-², number of paniclesm-²,number of  filled grains panicle^-1, 1000-grain weight, grain yield tha^-1 and straw yield tha^-1 were decreased as irrigation intervals were prolonged up 9 days in the two seasons of study. On the other hand, the period from sowing to heading was prolonged and sterility% was increased. Harvest index wasn't affected by irrigation intervals in both seasons. Both irrigation intervals of CF and 6 days were at a par regarding rice grain yield of both seasons of study while, panicles number/m-² and filled grainspanicle^-1 showed the same pattern in 2012 season. Water use efficiency was found to be optimum with irrigation interval of 6- days, with water save % amounted to be 6.93- 5.78..Meanwhile, prolonged irrigation interval up to 9 days gave the highest of water save %( 18.8-19.5%) and yield reduction.Increasing nitrogen level up to 220 kg Nha^-1 significantly increased all studied traits without significant differences with those produced by 165 kg Nha^-1 in most assessed traits and rice grain yield in both seasons of study. On controversy, sterility% significantly decreased as nitrogen level was increased up to 165kgNha^-1 while beyond the latter level the sterility% started to slightly increase. Increasing nitrogen level clearly increased water use efficiency.The interaction effect had significant effect on flag leaf area, leaf area index, plant height, number of tillersm^-2, number of paniclesm^-2, filled grains number/panicle, sterility%, 1000-grain weight, grain and straw yields in both seasons of study.  The interaction effect had no significant effect on heading date, chlorophyll content and harvest index in both seasons.The interaction effect came to confirm that the irrigation every 6 days with 165 kg Nha^-1 was being to be effective in increasing water use efficiencies, water save and maintain reasonable grain yield.Under prolonged irrigation interval, increasing nitrogen level could relief the harmful of water stress. It could be concluded that the nitrogen level of 165 kg Nha^-1 and irrigation every 6-day is relevant for drilled Giza 179 rice variety providing high water use efficiency with high yield and reasonable water save percentage.