Laboratory and field experiments were conducted to estimate the effect of fungal disinfectant (Tendro 40% FS) and seed drying treatments and their interaction on physiological quality and field performance of wheat seed. Seeds were exhibited to the fungal disinfectant concentrations i.e., 5cm³kg^-1, 3cm³kg^-1 and 7cm³kg^-1 seed in addition to undressed seed as control treatment, while the second factor was seed drying treatments i.e., natural drying (indirect sunlight), interrupted drying (hot air dryer) and rapid drying (oven dryer). Factorial experiment in RCD and RCBD with 4 replicates were set to perform laboratory and field experiments, respectively. All fungal disinfectant concentrations significantly enhanced the germination indices over the untreated seed, while 5cm³kg^-1 treatment showed the greatest increase upon control of G% (5.4%), FE% (7.4%), SDW (40%) and (23%), SVI (46.2%) and (27.2%) of laboratory and field performance, respectively. SMC ranged from 11.18%, 11.07% and 11.0% for natural, interrupted and rapid drying treatments, respectively. More, rapid drying recorded the highest loss of water in the shortest period of drying which was 4h(4h×1day), followed by interrupted and natural drying treatments which recorded 8h(4h×2days) and 24h(6h×4days), respectively. Moreover, the interrupted drying significantly permits the higher values of G% (93.5%), FE% (87.8%), SDW (0.20_g) and (0.17_g) and SVI (0.19) and (0.15) of laboratory and field performance, respectively. Finally, the interaction treatments showed no significant effect but on MGT_day trait, more treatment 5cm³kg^-1×8h of interrupted drying showed the highest seed physiological and field performance values upon the other interaction treatments.