Two field experiments had conducted in of 2012 and 2013 summer seasons at Deir Mawas, Menia Governorate, Egypt to study the effect of irrigation amounts applied with center- pivot sprinklers and fertilization on yield and quality of soybean. The results indicated that application of 2880 m³ /feddan (4200 m²) significantly surpassed application of 2240 and 1600 m³ /feddan in plant height, number of pods and seeds/plant, seed index and seed yield/plant. The highest seed yield/fed. was obtained with irrigation by 2880 m³ /fed., which was 52.2 % higher than irrigation with 1600 m³ /fed. (0.620 ton/fed.). The maximum oil content (20.74 %) and protein content (41.79) had achieved with irrigating by 2240 m³/feddan. However, the highest yields of oil (266.52 kg/fed) and protein (534.88 kg/feddan) had obtained from irrigation by 2880 m³ water/feddan. The highest soybean plant height, number of pods and seeds/plant, seed index and seed yield/plant were obtained with addition of NPK compound (19:19:19) with15 units of each elements (F2). In addition, F2 fertilizer treatment recorded the highest values of seed, oil and protein yields/feddan and IWUE. On the other hand, application of NPK compound (19:19:19) with 7.5 Kg of each element/feddan(F4) produced the highest oil and protein contents in seeds (21.28 and 43.06 %, respectively). The interactions between the amounts of irrigation and fertilizer treatments revealed highly significant differences in plant height, number of seeds/plant, seed index, seed yields per plant and feddan, oil and protein contents and yields. Irrigation by 2880 m3 /feddan with addition NPK compound (19:19:19) with 15 Kg of each element/ feddan significantly gave the greatest values of plant height, seeds/plant, seed index, seed yield/plant and yields/feddan of seed, oil and protein.