The genetic parameters controlling the expression of foliage disease resistance, seed yield and its components of faba bean have been studied using the generation mean analysis, during 2012/13, 2013/14 and 2014/15 seasons at Sakha Agricultural Research Station, Kafr El-Sheikh, Egypt. The six population parameters P₁, P₂, F₁, F₂, BC₁ and BC₁   of three faba bean crosses (Giza 3 x Rena Mora , Sakha 1 x Ohshima-Zairai and Sakha 2 x Rena Mora) were used in this study. The obtained results indicated that both additive and dominance types of gene effects were involved in the inheritance of No. of seeds/plant, seed yield/plant, No. of seed/pod, 100-seed weight and reaction to chocolate spot and rust diseases in the three crosses, moreover, additive x additive gene effects were relatively more important than additive effects in the inheritance of these traits but less important than dominance ones. Significant and negative mid parental heterosis was detected for days to flowering in the second cross, days to maturity in the first and second cross and reaction to chocolate spot and rust diseases in the three crosses as a result of partial dominance towards lower parent but the better parental heterosis did not exceed or reach the performance of the better parent for these traits. Significant negative values of breeding depression were obtained for these traits indicating that the depression were occurred due to inbreeding. Highly significant positive heterosis over both mid and better parent were detected for No. of branches/plant in the second and third cross, No. of pods/plant in the first and second cross, No. of seeds/plant in the first cross and seed yield /plant in the first and third cross, however, dominance  especially over-dominance as the potence ratio seems to be more contributing than epistasis in the expression of this valuable heterosis. The inbreeding depression estimates were positive and significant and/or highly significant for No. of branches/plant and No. of seeds/plant in the second and third cross, No. of seeds/plant and seed yield/plant in the second cross and chocolate spot and rust diseases reaction in the first cross, while it was negative and significant for chocolate spot and rust diseases reaction in the second and third cross. High genetic gain upon selection was found to be associated with high narrow sense heritability values and high estimates of GCV% and PCV% for No. of branches/plant, No. of pods/plant and No. of seeds/pod in the three crosses, indicating the effectiveness of selection for these traits.