A field experiment was conducted at El-Kanater Horticultural Research Station in the two seasons of 2013/14 and 2014/15 to study the effect of two soil moisture levels (25 % and 50 % of available soil moisture i.e.  medium and dry)  under drip and surface irrigation systems and three sources of N- fertilizers, namely urea  ( 46.5% N), ammonium nitrate ( 33.5% N) and ammonium sulphate ( 20.5% N) at the rate of 50 kg N/fed., as well as their interactions on  applied irrigation water, water use efficiency, growth, yield quality and chemical composition  of  lettuce  (Lactuca sativa L.)cv. Balady  .    Results indicate that surface irrigation system showed higher applied irrigation water under 25% and 50% of the available soil moisture than the drip irrigation system during 2013/14 and 2014/15 seasons. Drip irrigation system supported an increase of water use efficiency (23.84 and 22.57 kg/m³) in the first and the second seasons, respectively . Ammonium sulphate application  slightly increased the water use efficiency W.U.E (23.65 and 24.16 kg/m³) in the two seasons, respectively. Results of the interaction indicate that   the medium moisture (25 %) and Ammonium sulphate application  under drip and surface irrigation systems increased all studied growth characters, yield and nutrient uptake of lettuce .