Two pot experiments were carried out during two seasons of 2014 and 2015 on four grapevine rootstocks namely, Salt creek, Freedom, 1103 Paulsen and Harmony under shad (siran) house at pomology department, Fac. of Agric., Cairo Univ., Egypt. This study aimed to investigate the efficiency of previous rootstocks in uptake nitrogen and potassium nutrients as their effect on growth parameters. Four nitrogen and potassium rates (0.0, 0.4, 0.8, and 1.2 g N or K₂O/pot) were added separately in the two separate experiments and each rate was divided into six equal doses which added weekly. Freedom rootstock recorded the highest growth vigor parameters with regard to shoot and root length and dry weight followed by Salt Creek rootstocks all along both experiments. Also, Freedom recorded the highest significant leaf area in the first season in both experiments. Moreover, Freedom rootstock contained the highest nitrogen and potassium content in shoot and root tissues. Furthermore, the highest nutrient dosages (0.8 and 1.2 g/pot) recorded the highest growth parameter, chlorophyll, nitrogen and potassium content. This study showed an additional advantage for Freedom rootstock in uptake and utilization of nitrogen and potassium nutrients.