Two field experiments were conducted at the private Farm in Mansoura, Dakahlia Governorate, Egypt, during 2013/2014 and 2014/2015 seasons to improve some wheat cultivars productivity under organic, mineral and foliar fertilization.        The experiments were carried out in a strip-split plot design with three replications. The vertical plots were assigned to organic manure (compost) and mineral nitrogen combination treatments. The Horizontal plots were devoted to foliar fertilization treatments (commercial foliar fertilizers). While, the sub – plots were allocated to wheat cultivars (Sakha 93, Giza 168 and Gemmiza 10). The obtained results showed that application of 100 % (214 kg N/ha) as mineral nitrogen alone increased all growth characters, yield and yield components as well as crude protein percentages in grains as compared with other compost and mineral nitrogen combination treatments. However, application of 25 % compost (53.5 kg N/ha) + 75 % mineral nitrogen (160.5 kg N/ha) came in the second rank in both seasons. Spraying wheat plants with Biohealth which considered as biostimulants foliar fertilizer produced the highest values of wheat growth, yields and its components and quality character and followed by spraying with Stimufol as macro and micro nutrients foliar fertilizer in both seasons. Gemmiza 10 cultivar surpassed other studied cultivars (Giza 168 and Sakha 93) and recorded the highest values of most studied characters in both seasons. Giza 168 cultivar registered the longest spikes and the highest values of protein percentage in grains. Whereas, Sakha 93 cultivar recorded the highest values of 1000 – grain weight at the same time the lowest values of other studied characters. It could be recommended that fertilizing Gemmiza 10 cultivar with 25 % compost (53.5 kg N/ha) + 75 % mineral nitrogen (160.5 kg N/ha) and foliar spraying with commercial foliar fertilizer Biohealth to enhance wheat productivity and also to reduce sources of environmental pollution and maintain human health.