Two field experiments were conducted at Gemmeiza Agric. Res. Stat. during 2011/12 and 2012/13 growing seasons, to study the influence of different irrigation regimes i.e. irrigation at tillering stage (I₁), at tillering and heading stage (I₂) and at tillering , heading and grain filling stage (I₃) with three methods of sowing i.e. broadcasting, drilling and beds sowing on yield and its components of four wheat cultivars namely Gemmeiza-11, Misr-1, Shandaweel-1 and Sids-12.A significant reductions in grain and straw yields in both seasons was obtained as a result to subjecting wheat plants to drought-stress. Results showed that three irrigations increased significantly number of spikes/m², number of grains/spike, 1000-grain weight, grain weight/spike, biological yield and harvest index except protein content. It could be noticed beds sowing method gave highest yield components. Gemmeiza-11 wheat cultivar surpassed the other tested cultivars concerning with the above mentioned traits, except number of spikes/m² and straw yield. While, Misr-1 surpassed in no. of spikes in both seasons and harvest index in the second season, however, Shandaweel-1 produced the highest protein content. A significant interactions between the effect of irrigation (I), sowing methods (M) and wheat cultivars (V) were found in increasing the yield and its components, except between irrigation and sowing methods (I x M) concerning with grain weight/spike (g), grain yield (ardab/fad), straw yield (ton/fad) and biological yield (ton/ fad) in the second season only. Correlation positive and significant relationships between grain yield/fad and all yield components.                 It could be concluded that to get highest productivity of wheat under middle delta region conditions it must cultivate Gemmeiza-11 cultivar with addition of three irrigations with using the beds sowing method.