Barley is one of the major cereal crops cultivated in new reclaimed sandy soils. In order to decrease nitrogen pollution in barley fields, an trail was conducted to compensate barley inorganic nitrogen needs by organic manure under newly reclaimed sandy saline soils in North Nile Delta during 2011/2012 and 2012/2013 seasons at Experimental Station Farm, Faculty of Agriculture, Mansoura University, Egypt. A strip-plot design with four replicates was used. The vertical plots were occupied with three barley cultivars (Giza 129, Giza 130 and Giza 131). While, the horizontal-plots were devoted to five combination treatments of inorganic nitrogen and poultry manure i.e. 100% inorganic nitrogen, 75% inorganic nitrogen + 25 % poultry manure, 50% inorganic nitrogen + 50 % poultry manure, 25% inorganic nitrogen + 75 % poultry manure and 100 % poultry manure. The results indicated that Giza 131cultivar surpassed other studied cultivars (Giza 129, Giza 130 cultivars) in all studied characters and recorded the maximum values in both seasons. Application of 75% inorganic nitrogen plus 25% poultry manure combination treatment recorded the highest values of all studied characters, followed by 100% inorganic nitrogen fertilizer, then 50% inorganic nitrogen and 25% poultry manure combination treatment, 25% inorganic nitrogen and 75% poultry manure combination treatment, and lastly 100% poultry manure only in both seasons. On the basis of the results obtained, maximum grain and straw yields of barley resulted by fertilizing Giza 131 cultivar with 75% inorganic nitrogen beside 25% poultry manure under sandy saline soils in North Nile Delta.