This study was conducted under greenhouse conditions at Kaha Vegetable Research Farm (KVRF), Kalubia Governorate, Egypt through the period from 2011 to 2014. The objective of this work was to produce newly recombinant inbred lines (RILs) in cantaloupe using single seed decent (SSD) breeding method for seven successive generations. Four superior commercial hybrids of cantaloupe grown under Egyptian conditions viz., Primo, Mirella (galia type), Magenta and Kousto (charentais type) were utilized as a genetic materials in this work. The F₈ seeds of twenty five cantaloupe RILs were selected and sown in the open field during early summer season of 2014 at KVRF to be characterized the RILs that they were had distinctness, uniformity and stability (DUS). Also, the value for cultivation and use (VCU) was used to determine the value of RILs as a cantaloupe genetic resources. In addition, to estimate the coefficient of variance (CV %) within and between the selected RILs, gain of selection and broad sense heritability were used. The results confirmed that the SSD breeding was effective and time saving method in cantaloupe. It was produced 25 selected RILs. The selected RILs had DUS, high fruit quality and yield. The CV % within selected RILs was very low except for RIL 176, but between it was very high which confirmed the DUS test results. This indicated  that the selected RILs had very high homogeneity within it and large genetic distance between it. All studied traits had high heritability which ranged from 69.52 to 93.64 %, as well as, most of these traits gave high gain of selection. High heritability indicates less environmental influence in the observed variation. Also, high heritability coupled with high gain of selection for given traits which indicated that it is governed by additive gene action to be provides the most effective condition for selection. Finally, these selected RILs considered as a best resources to be used for cantaloupe improvement.