Most of farmers in Kafr El-Sheikh area accustomed to grow pea as cash vegetable crop in the short period lied between summer and winter crops before growing summer season and they need to control weeds in such crop. Thus, this investigation was carried to study the response of pea plant Master B, variety and their associated weed in two field experiments were during 2013/2014 and 2014/2015 winter seasons at Sakha Horticultural Research Station Farm, Kafr El-Sheikh Governorate. A split plot in a randomized complete blocks design with four replications was used. Where the response of pea plants, two inoculated with the rhizobium bacteria and someweed control treatments.The main plots included rhizobium bacteria inoculation and uninoculated control, the sub plots included eight weed control treatments i.e pendimethalin at 1.7L/fed, pendimethalin at 1.25L/fed plus hand hoeing once, pendimethalin at 1.0 L/fed plus hand hoeing twice; butralin at 2.5L/fed; butralin at 2.00 L/fed plus hand hoeing once; butralin at 1.0 L/fed plus hand hoeing twice, hand hoeing twice and untreaded control. The main findings in this study were as follow: Rhizobial inoculation with pea seeds caused significant increases in both seasons in number of nodules plant^–1, fresh, dry weight of nodules plant^–1 and increased yield ton/fed by (58.1, 37.5, 37.5 and 16.7%), in 2013/2014 season and (57.9, 35.3, 38.5 and 22.7%), in 2014/2015 season, respectively.This was accompanied improving pea plant growth characteristics caused indirection suppressed on the dry weight of weeds, than non-inoculation seeds treatment condition and increasing competitiveness of pea plant. There is no approves inhibition effects on bacterial nodules formation the use herbicides on number of nodules plant^–1, fresh and dry weight of nodules plant^–1 except with pendimethalin at 1.7L/fed, which decreased the fresh and dry weight of nodules plant^–1 by (46.7 and 37.5%), in 2013/14 season and, (47.1 and 41.7%), in 2014/15 season. All weed control treatments reduced dry weight of broadleaf, grassy and total weeds due to weed species susceptibility to herbicidal the use herbicidal as compared with untreated control. The effective weed control treatments could be arranged in a descending order according to their depressing the dry weight of total weeds increasing peas yield and its components as follows: butralin at 2.00 L/fed plus hand hoeing once and increased pea yield by (72.7 and 76.9%), in 2013/14 season and (70.4 and 75.0%), in 2014/15 season than untreated check.The effect of interaction between with rhizobial inoculation and weed control treatments on bacterial nodules were statistically significant in both seasons. Most herbicidal treatments under uninoculation condition inhibited to somewhat number of nodules/plant, fresh and dry weight of nodules/plant except with some treatments which were similar its untreated check and rhizobial inoculation with herbicidal treatments can be help bacterial nodules recovery from the sides effects of herbicide. Meanwhile, the previous interaction gave 95% weed control accompanied increase in pea yield ton/fed with applying rhizobial and adding, butralin at 2L/fed plus hand hoeing once, where improved of weed control and enhancing pea growth with rhizobial inoculation other interaction were discussed as show in manuscript of paper. The dry weight of total weeds biomass was correlated indicating negative with pea yield indicating to the severity of weed competition on pea yield and its components which may be attributed directly to the improvement of weed control in one side and enhancing the grow of pea/plants by increasing effective bacterial nodules in fixing nitrogen in the other sides. Thus, we can recommend farmers to inoculate pea seeds with rhizobial inoculation and use the proper herbicidal treatments to control weeds in pea field as good alternative to mechanical hand hoeing.