Two field experiments were carried out at private farm Amoun Agricultural Society, AL-tal El Kabier, Ismailia Governorate, Egypt during the two successive winter seasons of 2013/2014 and 2014/2015 to study effect of using some anti-cold stressors or anti-oxidants compounds on minimizing cold injury on tomato plants  grown in sandy soil under drip irrigation system. The compounds used were Phosphor X, Pepton 85/16 , Amcoton, Calcium citrate, Zinc citrate , Potassium citrate , Potassin-F, Ascopen comparing with the untreated control. These compounds applied as foliar spray on the vegetative growth four times starting at the beginning of flowering stage and repeated every 10 days.The obtained results showed that, all compounds used in these study induced positive effect on reducing cold injury of the low temperature during the growing season, i,e October , November , December , January months comparing with the control . The superior treatments in this regard were the foliar spray with Phosphor X, Pepton 85/16, Amcoton while, the other treatments showed medium effects.  Phosphor X, Pepton then Amcoton registered the high values in cold tolerance, i.e., induced higher degrees of minimizing chilling injury, while the lowest value of minimizing chilling injure was obtained from the control. In addition, the same favorable treatments i,.e : the foliar spray with Phosphor X, or Pepton then Amcoton showed excellent influence on the vegetative growth, fruit setting, fruit yield and its quality of tomato plants grown in winter season under sandy soil .So it can be recommend that spraying tomato plant during the winter months by some anti-cold stress treatments such as Phosphor X, or Pepton then Amcoton respectively for the purpose of minimizing chilling injury and enhancing the vegetative growth and giving high fruit yield with best quality.