A field experiment was conducted during 2014 and 2015 seasons at El-Sirw Agricultural Research Station, Damietta, Egypt. The present study was conducted to identify the response of rice cultivar Giza 179 to phosphorus (P) and sulfur (S) fertilizers application under saline soil conditions. The average of salinity levels of experimental site were 7.9 and 7.5 dS m^-1 in 2014 and 2015 seasons, respectively. Split plot design with four replications was used. The treatments comprised the response of rice cultivar Giza 179 to four phosphorous rates namely; 0, 36, 54 and 72 kg P₂O₅ ha^-1 and four sulfur rates viz; 0, 120, 240 and 360 kg S ha^-1. Some growth characteristics, grain yield and yield components of rice were estimated. However, the economic evaluation was assessed. The main results could be summarized as follows; the P and S treatments significantly improved rice growth criteria i.e. leaf area index, chlorophyll content, dry matter production, number of tillers hill^-1, plant height, yield components; number of panicles hill^-1, panicle length, panicle weight, number of filled grains panicle^-1 and 1000-grain weight, grain and straw yields and harvest index compared to control treatment. The treatment of 54 kg P₂O₅ ha^-1 gave the highest values of all above mentioned traits and also, the treatment of 240 kg S ha^-1 gave the highest values of them without any significant difference with 120 kg S ha^-1. The interaction between P and S significantly affected LAI, plant height, number of panicles hill^-1, grain and straw yields especially with the combination of 54 kg P₂O₅ ha^-1 and 240 kg S ha^-1. From economic evaluation, the highest grain yield increase over control (t ha^-1), profitability (LE ha^-1) and net return were obtained with the treatment of 54 kg P₂O₅ ha^-1 and 120 kg S ha^-1. It sum up that application of 54 kg P₂O₅ ha^-1  and  120 kg S ha^-1 is enough to obtain higher grain yield and economic return under the present study and similar conditions.