Two greenhouse experiments were conducted at the experimental farm of the Faculty of Agriculture, TantaUniversity, Tanta, Egypt, during 2013/2014 and 2014/2015 seasons. The aim of this research is to study the effect of different levels of mineral fertilizers )50, 75 and 100% of recommended dose ‘RD') with some bio-fertilizers, i.e. Easterna  biofert (commercial bio-fertilizer) and a mixture of Rhizobacterin, Phosphorein and Potassiumage on the growth, yield and fruit quality of sweet pepper plants (Capsicum annuum, L. cv. Gideon F1 hybrid). The experiment was designed in a completely randomized blocks (CRB) with four replicates. Results indicated that the maximum vegetative growth parameters, yield, fruit quality, and chemical composition of the plant leaves and fruits were recorded a result of the following treatments in descending order; application of 100% of RD of mineral fertilizer; 75% RD of mineral fertilizer mixed with phosphorein, potassiumage and rhizobacterin; 75% RD of mineral fertilizer combined with Easterna biofert; however there were no significant differences among these treatments. Application of 50% RD of mineral fertilizer with the bio fertilizers mixture, or with easterna biofert only was significantly reduced those parameters. It could be concluded that fertilizer mix of mineral fertilizes at 75 % RD   combined with phosphorein, potassiumage and rhizobacterin, or with easterna biofert only can improve the productivity and fruit characteristics of sweet pepper under greenhouse conditions. In addition to that, mixing mineral fertilizers with biofertilizers reduce the cost of chemical fertilizer, nitrate accumulation in the edible portion that affect human health, and environmental pollution.