This study was carried out at the Experimental Farm in Agronomy Department, Faculty of Agriculture, Mansoura University during the two seasons 2012/2013 and 2013/2014 using six diverse barley genotypes (Hordeum vulgare  L.). All possible parental combinations without reciprocals were made among the six genotypes, giving 15 crosses. The six parental genotypes and 15 F₁'s were evaluated in two experiments. The first experiment, was irrigated with the recommended treatment i.e three irrigations after planting irrigation  (normal condition), and the second one was irrigated with planting irrigation only (drought condition). Plant height, spike length, number of grains/spike, number of spikes/plant, 100–grain weight and grain yield /plant were studied . Results indicated that water stress treatments decreased the means of all studied traits for parents and their hybrids. Statistical analysis revealed highly significant effects of genotypes, GCA and SCA for all studied traits, providing evidence for presence of large amount of genetic variability. The estimates of GCA effects showed that, P₁ was a good combiner for number of grains/spike and 100-grain weight under both conditions, spikes/plant under Normal and plant height and grain yield/plant under stress; P₂ for grain yield/plant under both conditions, spike length, spikes/plant, number of grains/spike under normal and plant height under stress ; P₃ for plant height, 100 grain weight under both conditions and number of grains/spike under normal; P₄ for grain yield/plant under both conditions, spikes/plant under normal and plant height under stress; P₅ for plant height and number of grains/spike under stress  and P₆ for spike length and 100 grain weight under stress. For SCA estimates, it could be summarized that the best hybrids were cross No. 1, 9 and 10 for most studied traits under both conditions. Drought susceptibility index (DSI) used to estimate relative stress injury because it accounted for variation in yield potential and stress intensity. This index could be estimated based on many traits. which included Giza 123, Giza 129, crosses No. 3 and 10 were  tolerant for most traits, indicating the importance of these parents in this regard.