The study was carried out during 2014 and 2015 growing seasons on pomegranate (Wonderful cv.) with five years old grown under sandy soil conditions in a private from located at Egypt – Alexandria desert road  (EL-Alamain in El-Behera governorate). The study aimed to investigate the influence of foliar spray with K, Ca, B and Ca combined with B nutrients on fruit yield and quality. Foliar spraying treatments were done two times at completely fruit set of June and August in trees both seasons with the following concentrations: calcium chloride at (1.5%, 3%), Potassium sulphate at (2%, 4%), Boric acid at (0.3 %) and combination between (calcium chloride at 1.5% + Boric acid at 0.3 %). The results of all treatments showed significantly increase fruit peel and grains but decreased percentage of splitting fruits compared with control (water spray). Also, all treatments increased significantly the average fruit yield whereas [calcium chloride (1.5%) + Boric acid (0.3 %)] scored the highest significant values for yield and physical and chemical characteristics of fruits. It could be recommended to use either calcium chloride (1.5%) plus boric acid to reduce fruit splitting and for giving the best yield and high fruit quality for pomegranate Wonderful cv. under the study conditions.