Rice diseases is the most destructive biotic constrains for high yield potential and cause breakdown of resistance. The objective of this investigation is to evaluate and screen some developed elite resistant rice genotypes for blast, bakanae and white tip nematode diseases with high yielding potentiality. Eighteen commercial and promising rice genotypes i.e., six varieties and 12 promising lines were evaluated for their agronomic traits, yield and resistance to various diseases under natural and artificial inoculation at experimental farm of Sakha Agricultural Research Station, Kafr El-Sheikh, Egypt during 2014 and 2015 seasons. Among studied traits, No. of filled grains panicle^-1 exhibited the highest estimates of genotypic coefficient of variation (GCV) and phenotypic coefficient of variation (PCV), followed by No. of panicles plant^-1. Broad sense heritability values were high for all studied traits and ranged from 91.06 % to 99.05 %. The promising lines SP70-6-4 and SP70-6-1 produced the highest grain yield with 11.73 and 11.72 t ha^-1 compared with its respective parent Sakha 101 (10.63 t ha^-1). The result of principal component analysis (PCA) showed that most important traits in divergence of evaluated genotypes were; filled grains panicle^-1 and showed the contribution of these parents Giza 178, GZ 6296, super rice varieties IR 66298, IR 65600. IR 66159 as good donors for improving filled grains panicle^-1. All the studied genotypes had wide range of genetic variability, therefore they provided broad spectrum of blast resistance levels. The three developed lines; GG-46-2006, GG-42-1 and GG-42-2 were highly resistant to blast. The super rice genotypes; IR 66298, IR 65600, IR 66159 and HR 5824 and the elite developed lines; GZ 5310 and BY 6-20 could be considered as promising donors to bakanae resistance. For white tip nematode, the derived lines from Giza 177 crossed to HR 5824 dropped the No. of nematodes per 10 g rice grains from 153.67 individual larvae to 0 and 1.67. The line BY 6-20 reduced the No. of nematodes to 4.33 comparing with 106 larvae of its parent Sakha 101. The highly resistant genotypes Giza 178, GZ 6296 and their derived lines recorded the lowest no. of nematodes ranged from 0.67 to 12.33. Giza 178, GZ 6296 and their derived line BY 6-20 were considered as good donors for white tip nematode resistance. The breeder successfully improved elite varieties; SP70-6-1, BY 6-20, Giza 178-1 and GG-46-2006, with wide spectrum of resistance level to blast, bakanae and white tip nematode. Giza 178 and GZ 6296 were considered as good donors of all tested diseases in breeding program.