The field experimentes were conducted during 2016 and 2017 rice growing seasons. The investigation aimed to study the effect of seed classes i.e. breeder, foundation, registered and farmer and the studied cultivars i.e. Sakha 101, Giza 177, and Giza 178 on the productivity of rice (Oriza sativa). Split plot design with three replications was used, the main plots were randomely occupied by four classes of seeds, while the cultivars Sakha 101, Giza 177, and Giza 178 were assigned to the sub plots. Results showed that, breeder seeds gave the highest grain yield (10.97 and 11.34 t ha-1) in 2016 and 2017 seasons, respectively. The highest grain yield (10.51 and 10.83 t/ha) was obtained from variety Sakha 101 in both seasons, respectively. The interaction between cultivars and seed classes was highly significant for germination (%), shoot length (cm), root length (cm), days to heading, number of tillers/hill, panicle weight (g), panicle length (cm), seed set (%), 1000-grain weight and grain yield, while not significant was found for plant height (cm) during 2016 and 2017 seasons. The results indicated that both of rice varieties and seed classes were important for increasing grain yield.