A field study was carried out at the experimental farm of Rice Department, Sakha, Kafr El-Sheikh, Egypt during 2016 and 2017 seasons to detect the effect of tillage technique and herbicides use on weeds and yield of transplanted rice. A strip plot design with four replicates was applied. Tillage techniques (Zero tillage + puddling, one tillage + puddling, two tillage + puddling and two tillage without puddling) were allocated in horizontal strips. Weed control treatments were weedy check, hand weeding, thiobencarb (Saturn 50 % EC) at recommended dose (2.4 kg ai ha^-1) and penoxsulam (Granite 24% SC) at recommended dose (0.029 kg ai ha^-1) were assigned as vertical plots. Weed flora and rice yields were considerably affected by tillage technique and weed control treatments. Cyperus difformis, Ammania sp., Scirpus sp. and total weeds dry weights were noticeably reduced fewer than two tillage + puddling plots than with other tillage technique. But Echinochloa crus-galli and Echinochloa colona were significantly reduced under zero tillage + puddling plots than under other tillage techniques. The highest values of panicles per unit area, panicle weight (g), filled grains / panicle, biological yield, grain yield (t ha^-1) and harvest index of rice (%) were recorded under two tillage + puddling plots followed by one tillage + puddling than under other tillage techniques. The application of penoxsulam resulted in the best weed control and best rice grain yield (t ha^-1) and its components under this study followed by the application of thiobencarb. Untreated (weedy check) plots gave the highest weed presence and the lowest rice yields and its components in 2016 and 2017 seasons under this study. For the interaction, the lowest values of dry weight for Echinochloa crus-galli, Echinochloa colona, Cyperus difformis, Ammania sp., Scirpus sp. and total weeds, in addition to the highest grain yield of rice was obtained under two tillage + puddling treated by penoxsulam 24% SC as the recommended dose during the two growing seasons.